The side effects of Androderm can include high blood pressure due to high levels of water retention. However, water retention is highly unlikely due to the low level dosing plans that will be prescribed and easily combatable with anti-estrogen medications if needed. The use of exogenous testosterone can also have a negative impact on cholesterol, particularly in the suppression or reduction of HDL cholesterol. However, therapeutic doses of testosterone to even moderate performance doses do not appear to have a strong, negative statistical impact on cholesterol when testosterone is used alone. When the use of an AI is conjoined with testosterone, this does appear to create a notable impact on HDL reductions. A negative impact cannot occur with the use of a SERM; in fact, SERM’s will actually improve cholesterol levels due to their estrogenic activity in the liver.
While cholesterol issues are possible, they are also easy to avoid. AI’s should not be used unless necessary, but even if necessary healthy cholesterol levels can be maintained with a healthy lifestyle. Limiting saturated fats and simple sugars is a good place to start along with plenty of omega fatty acids. Daily fish oil supplementation is recommended as is daily cardiovascular activity.
The partition coefficient of the ester in question is important because is effects how long the drug itself stays in the system. If the testosterone transfers too quickly from the oil to the blood, the result is a sudden spike in testosterone which then rapidly drops once the dose has been used up. In the example of free testosterone injected into the muscle from a water suspension (as in Aquiviron, mentioned above), the testosterone is essentially immediately available to the bloodstream due to its low partition coefficient, and thus there is an immediate spike of testosterone which is used up quickly in the body.