Androgens are responsible for the growth spurt of adolescence and for the eventual termination of linear growth, which is brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing the production of erythropoeitic stimulating factor. During exogenous administration of androgens,Â endogenous testosterone Â release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH).
Becauseofthemildanti-cho-linergic effect of orphenadrine, Orphengesic (orphenadrine citrate, asprin and caffeine tablets) Tablets, or Or-phengesicForteTabletsshould not be used in patients with glaucoma , pyloric or duodenal obstruction, achalasia , prostat-ic hypertrophy orobstructions at the bladder neck. Orphen-gesic Tablets or Orphengesic (orphenadrine citrate, asprin and caffeine tablets) Forte Tablets are also contraindicated in patients withmy-astheniagravis and in patients known to be sensitive to aspirin or caffeine .