Hey Ben, I recently had surgery to repair a full thickness tear of my supraspinatus (rotator cuff). I tried my first injection of 250 mcg. the following day in the trap area, because that was as close as I could get to the shoulder at that time. About 8 hours later I got extremely nauseous. It finally passed. The next day I did the same injection and again, about 8-10 hours later got very nauseous, eventually throwing up like I never had before. I skipped 2 days and had a little nausea off and on. Then I tried another injection and like clockwork, got extremely nauseous 7-8 hours later.