Sorry for such a dated reply, but this caught my eye while doing a search for epi. I'm not trying to be a fear monger or anything, but when it concerns your liver it's not that simple, especially when it concerns hormones. I'd really suggest checking this thread out, and familiarizing yourself with hepatic adenomas . If you keep your estro levels in check and run orals sparingly, you'll probably be fine. Especially if pre-loading with something like TUDCA. Epi is a pretty mild oral, so that again means you could be fine. Just know that certain people are going to be prone to problems like this, and for some people regular use of high amounts of hormones can cause issues that aren't noticeable without an ultrasound (as in liver values aren't always elevated, at least to a high or dangerous degree, while adenomas are growing).